Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice
Joint Authors
Alhusayan, Rana M.
Aldahmash, Badr Abdullah
El-Nagar, Doaa M.
Rady, Ahmad
Ibrahim, Khalid Elfakki
Alkahtani, Saad
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The liver is the most vital organ that could be influenced by inducers of hypersensitivity such as ovalbumin.
The current study was carried out to explore the effects of butterbur (Petasites hybridus) extract on the ovalbumin-induced liver hypersensitivity in Swiss albino male mice.
Animals were divided into 4 groups, 1st group served as a control group, 2nd group treated with daily oral administration of 75 mg/kg of butterbur extract, 3rd group received single oral dose 100 mg/kg of ovalbumin to induce hypersensitivity, and 4th group treated with oral administration of butterbur extract one-day post to the hypersensitivity induction.
Ovalbumin induces a significant increase in the activity of liver enzymes and MDA and decreased the activity of CAT after the ovalbumin treatment.
Histopathological investigations revealed marked pathological alterations in liver tissues in the form of hyaline degeneration and fibrosis.
Additionally, heavy immune response indicated by immunostaining of MDA and TNF-α could be observed.
In contrast, posttreatment with butterbur extract after hypersensitivity induction resulted in a significant decrease of liver enzymes and oxidative stress and reduced the inflammation and fibrosis of liver tissues.
These results suggest that butterbur extract is considered as anti-inflammatory and antioxidant therapeutic herb for hypersensitivity treatment of liver.
American Psychological Association (APA)
Alhusayan, Rana M.& Aldahmash, Badr Abdullah& El-Nagar, Doaa M.& Rady, Ahmad& Ibrahim, Khalid Elfakki& Alkahtani, Saad. 2020. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204192
Modern Language Association (MLA)
Alhusayan, Rana M.…[et al.]. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1204192
American Medical Association (AMA)
Alhusayan, Rana M.& Aldahmash, Badr Abdullah& El-Nagar, Doaa M.& Rady, Ahmad& Ibrahim, Khalid Elfakki& Alkahtani, Saad. Butterbur (Petasites hybridus) Extract Ameliorates Hepatic Damage Induced by Ovalbumin in Mice. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1204192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204192