Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats
المؤلفون المشاركون
Balgoon, Maha Jameal
Ayuob, Nasra
El-Mansy, Ahmed A.
Mubarak, Wafaa A.
Firgany, Alaa El-Din L.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-21
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
The association between hypothyroidism and renal diseases has been described in many studies.
Nigella Sativa was among the recently reported natural product that has the potential to prevent renal tissue damage and fibrosis.
The aim of this study was to evaluate the possible protective effect of thymoquinone on the structure of the renal cortex of hypothyroid rats and explore the mechanism behind it.
Methods.
An experimental model of hypothyroidism was induced in adult male Wistar rats by administration of propylthiouracil (6 mg/kg/body weight).
One hypothyroid group was treated with thymoquinone at the dose of 50 mg/kg/body weight and compared to the untreated group.
Thyroid function and oxidant/antioxidant status were assessed in the serum.
Catalase gene expression was assessed using the real-time polymerase chain reaction.
The kidney was assessed both histologically and immunohistochemically.
Results.
Administration of propylthiouracil resulted in a significant decrease in the serum levels of nitric oxide, reduced glutathione, and superoxide dismutase activity while the level of malondialdehyde significantly (p<0.001) increased.
Administration of thymoquinone alleviated this effect on the thyroid hormones and significantly increased the serum levels of antioxidants.
Thymoquinone significantly (p<0.001) upregulated catalase transcription by about 24-fold and could block the hypothyroidism-induced glomerular and tubular injury.
Conclusion.
Thymoquinone may have a potential protective effect against hypothyroidism-induced renal injury acting through the attenuation of the oxidative stress and upregulation of renal catalase gene expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ayuob, Nasra& Balgoon, Maha Jameal& El-Mansy, Ahmed A.& Mubarak, Wafaa A.& Firgany, Alaa El-Din L.. 2020. Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204237
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ayuob, Nasra…[et al.]. Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1204237
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ayuob, Nasra& Balgoon, Maha Jameal& El-Mansy, Ahmed A.& Mubarak, Wafaa A.& Firgany, Alaa El-Din L.. Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of Propylthiouracil-Induced Hypothyroid Rats. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1204237
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204237
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر