SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes
المؤلفون المشاركون
Zhang, Tiantian
Chen, Yizhe
Cai, Jiarui
Pan, Miao
Sun, Qian
Zhang, Jing
Sun, Chao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-14
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Suppressor of cytokine signaling 2 (SOCS2) plays an important role in fat deposition, skeletal muscle, central nervous system development, and mitochondria biogenesis.
Nevertheless, the regulatory mechanisms of SOCS2 on mitochondrial fatty acid oxidation (FAO) remain unclear.
Leptin could inhibit food intake and increase thermogenesis through leptin receptor (LepR), which was present in the hypothalamus and certain peripheral organs, including adipose tissue.
With strong interest, we focused on the connection between leptin and SOCS2 and their effect on FAO in adipocytes.
In our study, we found that the mRNA level of SOCS2 and the protein levels of PGC-1α, CPT-1b, FAT, and p-ACC were elevated by leptin in the inguinal adipose tissue of mice.
On the contrary, the protein levels of FABP4, FATP1, and FAS were declined.
The genes related to fatty acid oxidation such as PGC-1α, NRF-1, TFAM, CPT-1b, AOX1, COX2, and UCP2 were attenuated by SOCS2, but elevated by leptin.
Moreover, fatty acid oxidation enzyme MCAD, LCAD, and Cyt C levels were reduced in response to SOCS2.
These reductions correspond well with the reduced release of free fatty acid and the reduction of mitochondrial complexes I and III by SOCS2.
Furthermore, JAK2/AMPK pathway-specific inhibitors could block the mitochondrial FAO; hence, this pathway was implied to have a potential impact on FAO.
Together, these studies suggested that SOCS2 had a negative effect on mitochondrial fatty acid oxidation, and the LepR/JAK2/AMPK pathway played a crucial role in this process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Tiantian& Chen, Yizhe& Cai, Jiarui& Pan, Miao& Sun, Qian& Zhang, Jing…[et al.]. 2020. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204341
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Tiantian…[et al.]. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1204341
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Tiantian& Chen, Yizhe& Cai, Jiarui& Pan, Miao& Sun, Qian& Zhang, Jing…[et al.]. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204341
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204341
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر