SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes
Joint Authors
Zhang, Tiantian
Chen, Yizhe
Cai, Jiarui
Pan, Miao
Sun, Qian
Zhang, Jing
Sun, Chao
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-07-14
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Suppressor of cytokine signaling 2 (SOCS2) plays an important role in fat deposition, skeletal muscle, central nervous system development, and mitochondria biogenesis.
Nevertheless, the regulatory mechanisms of SOCS2 on mitochondrial fatty acid oxidation (FAO) remain unclear.
Leptin could inhibit food intake and increase thermogenesis through leptin receptor (LepR), which was present in the hypothalamus and certain peripheral organs, including adipose tissue.
With strong interest, we focused on the connection between leptin and SOCS2 and their effect on FAO in adipocytes.
In our study, we found that the mRNA level of SOCS2 and the protein levels of PGC-1α, CPT-1b, FAT, and p-ACC were elevated by leptin in the inguinal adipose tissue of mice.
On the contrary, the protein levels of FABP4, FATP1, and FAS were declined.
The genes related to fatty acid oxidation such as PGC-1α, NRF-1, TFAM, CPT-1b, AOX1, COX2, and UCP2 were attenuated by SOCS2, but elevated by leptin.
Moreover, fatty acid oxidation enzyme MCAD, LCAD, and Cyt C levels were reduced in response to SOCS2.
These reductions correspond well with the reduced release of free fatty acid and the reduction of mitochondrial complexes I and III by SOCS2.
Furthermore, JAK2/AMPK pathway-specific inhibitors could block the mitochondrial FAO; hence, this pathway was implied to have a potential impact on FAO.
Together, these studies suggested that SOCS2 had a negative effect on mitochondrial fatty acid oxidation, and the LepR/JAK2/AMPK pathway played a crucial role in this process.
American Psychological Association (APA)
Zhang, Tiantian& Chen, Yizhe& Cai, Jiarui& Pan, Miao& Sun, Qian& Zhang, Jing…[et al.]. 2020. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204341
Modern Language Association (MLA)
Zhang, Tiantian…[et al.]. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-21.
https://search.emarefa.net/detail/BIM-1204341
American Medical Association (AMA)
Zhang, Tiantian& Chen, Yizhe& Cai, Jiarui& Pan, Miao& Sun, Qian& Zhang, Jing…[et al.]. SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepRJAK2AMPK Signaling Pathway in Mouse Adipocytes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-21.
https://search.emarefa.net/detail/BIM-1204341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204341