Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease
المؤلفون المشاركون
Sun, Ting
Luo, Xin
Ding, Zhe-Xu
Liu, Qing-Shan
Cheng, Yong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is a common and complex neurodegenerative disease; the pathogenesis of which is still uncertain.
Exosomes, nanosized extracellular vesicles, have been suggested to participate in the pathogenesis of PD, but their role is unknown.
Here, a metabolomic analysis of serum and brain exosomes showed differentially expressed metabolites between 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride- (MPTP-) induced PD mice and control mice, such as oxidized lipids, vitamins, and cholesterol.
These metabolites were enriched in coenzyme, nicotinamide, and amino acid pathways related to PD, and they could be served as preclinical biomarkers.
We further found that blood-derived exosomes from healthy volunteers alleviated impaired motor coordination in MPTP-treated mice.
Results from immunohistochemistry and western blotting indicated that the loss of dopaminergic neurons in substantia nigra and striatum of PD model mice was rescued by the exosome treatment.
The exosome treatment also restored the homeostasis of oxidative stress, neuroinflammation, and cell apoptosis in the model mice.
These results suggest that exosomes are important mediators for PD pathogenesis, and exosomes are promising targets for the diagnosis and treatment of PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Ting& Ding, Zhe-Xu& Luo, Xin& Liu, Qing-Shan& Cheng, Yong. 2020. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204346
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Ting…[et al.]. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204346
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Ting& Ding, Zhe-Xu& Luo, Xin& Liu, Qing-Shan& Cheng, Yong. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204346
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204346
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر