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Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease
Joint Authors
Sun, Ting
Luo, Xin
Ding, Zhe-Xu
Liu, Qing-Shan
Cheng, Yong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Parkinson’s disease (PD) is a common and complex neurodegenerative disease; the pathogenesis of which is still uncertain.
Exosomes, nanosized extracellular vesicles, have been suggested to participate in the pathogenesis of PD, but their role is unknown.
Here, a metabolomic analysis of serum and brain exosomes showed differentially expressed metabolites between 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride- (MPTP-) induced PD mice and control mice, such as oxidized lipids, vitamins, and cholesterol.
These metabolites were enriched in coenzyme, nicotinamide, and amino acid pathways related to PD, and they could be served as preclinical biomarkers.
We further found that blood-derived exosomes from healthy volunteers alleviated impaired motor coordination in MPTP-treated mice.
Results from immunohistochemistry and western blotting indicated that the loss of dopaminergic neurons in substantia nigra and striatum of PD model mice was rescued by the exosome treatment.
The exosome treatment also restored the homeostasis of oxidative stress, neuroinflammation, and cell apoptosis in the model mice.
These results suggest that exosomes are important mediators for PD pathogenesis, and exosomes are promising targets for the diagnosis and treatment of PD.
American Psychological Association (APA)
Sun, Ting& Ding, Zhe-Xu& Luo, Xin& Liu, Qing-Shan& Cheng, Yong. 2020. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204346
Modern Language Association (MLA)
Sun, Ting…[et al.]. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204346
American Medical Association (AMA)
Sun, Ting& Ding, Zhe-Xu& Luo, Xin& Liu, Qing-Shan& Cheng, Yong. Blood Exosomes Have Neuroprotective Effects in a Mouse Model of Parkinson’s Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204346