Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome
المؤلفون المشاركون
Wattanathorn, Jintanaporn
Palachai, Nut
Muchimapura, Supaporn
Thukham-mee, Wipawee
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-11
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Due to the antimetabolic syndrome effect of mulberry and ginger together with the advantages of the synergistic effect and phytosome encapsulation technique, we hypothesized that phytosome containing the combined extracts of mulberry and ginger (PMG) should be able to manage MetS.
PMG was developed and assessed the phenolic content and biological activities associated with the pathophysiology of MetS.
The antimetabolic syndrome effect and the possible underlying mechanisms in the animal model of MetS were also assessed.
Male Wistar rats induced MetS by subjecting to a 16-week high-carbohydrate high-fat diet.
MetS rats were orally given PMG at doses of 50, 100, and 200 mg/kg for 21 days.
They were determined metabolic parameter changes in serum, histomorphology changes of adipose tissue, the inflammatory cytokines such as IL-6 and TNF-α, oxidative stress status, PPAR-γ, and HDAC3 in adipose tissue.
Our in vitro data showed that PMG increased phenolic contents and biological activities.
PMG significantly improved MetS parameters including body weight gain, lipid profiles, plasma glucose, HOMA-IR, and ACE.
In addition, the density and size of adipocyte, adiposity index, and weights of adipose tissues were also improved.
Moreover, the decrease in TNF-α and IL-6, oxidative stress status, and HDAC3 expression together with the increase in PPAR-γ expression in adipose tissue was also observed.
These data suggest that PMG exhibit antimetabolic syndrome and the possible underlying mechanism may be associated partly with the modulation effect on HDAC3, PPAR-γ, and adipose tissue.
In addition, PMG also improves oxidative stress and inflammation in MetS.
Therefore, PMG can be served as the potential supplement to manage MetS.
However, a clinical trial study is essential to confirm this health benefit.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Palachai, Nut& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Thukham-mee, Wipawee. 2019. Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204383
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Palachai, Nut…[et al.]. Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1204383
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Palachai, Nut& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Thukham-mee, Wipawee. Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204383
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204383
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر