Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome
Joint Authors
Wattanathorn, Jintanaporn
Palachai, Nut
Muchimapura, Supaporn
Thukham-mee, Wipawee
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-11
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Due to the antimetabolic syndrome effect of mulberry and ginger together with the advantages of the synergistic effect and phytosome encapsulation technique, we hypothesized that phytosome containing the combined extracts of mulberry and ginger (PMG) should be able to manage MetS.
PMG was developed and assessed the phenolic content and biological activities associated with the pathophysiology of MetS.
The antimetabolic syndrome effect and the possible underlying mechanisms in the animal model of MetS were also assessed.
Male Wistar rats induced MetS by subjecting to a 16-week high-carbohydrate high-fat diet.
MetS rats were orally given PMG at doses of 50, 100, and 200 mg/kg for 21 days.
They were determined metabolic parameter changes in serum, histomorphology changes of adipose tissue, the inflammatory cytokines such as IL-6 and TNF-α, oxidative stress status, PPAR-γ, and HDAC3 in adipose tissue.
Our in vitro data showed that PMG increased phenolic contents and biological activities.
PMG significantly improved MetS parameters including body weight gain, lipid profiles, plasma glucose, HOMA-IR, and ACE.
In addition, the density and size of adipocyte, adiposity index, and weights of adipose tissues were also improved.
Moreover, the decrease in TNF-α and IL-6, oxidative stress status, and HDAC3 expression together with the increase in PPAR-γ expression in adipose tissue was also observed.
These data suggest that PMG exhibit antimetabolic syndrome and the possible underlying mechanism may be associated partly with the modulation effect on HDAC3, PPAR-γ, and adipose tissue.
In addition, PMG also improves oxidative stress and inflammation in MetS.
Therefore, PMG can be served as the potential supplement to manage MetS.
However, a clinical trial study is essential to confirm this health benefit.
American Psychological Association (APA)
Palachai, Nut& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Thukham-mee, Wipawee. 2019. Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204383
Modern Language Association (MLA)
Palachai, Nut…[et al.]. Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-19.
https://search.emarefa.net/detail/BIM-1204383
American Medical Association (AMA)
Palachai, Nut& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Thukham-mee, Wipawee. Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-19.
https://search.emarefa.net/detail/BIM-1204383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204383