Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction
المؤلفون المشاركون
Liu, Chong
Chen, Qi
Zhou, Juan
Wang, Zhong
Wan, Xiang
Gu, Meng
Chen, Yanbo
Cai, Zhikang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
To investigate the effect of Nrf2 activator sulforaphane (SFN) on bladder compliance and the underlying mechanisms in a rat model of partial bladder outlet obstruction (BOO).
Methods.
Male 8-week-old Sprague-Dawley rats were divided into three groups.
BOO rats were given daily 0.5 mg/kg sulforaphane (BOO+SFN) or vehicle (BOO) intraperitoneally for 4 weeks, while sham-operated rats were treated with vehicle (Sham).
Bladder compliance, histological alteration, and collagen deposition were evaluated.
The expression levels of collagen I, collagen III, MMP-1, and TIMP-1 were measured by immunohistochemistry and western blotting.
Results.
BOO led to a significant decrease in bladder compliance.
The change was partially restored by SFN treatment.
The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment.
Moreover, the increased collagen I/collagen III ratio in the BOO group was reversed by SFN treatment.
Conclusions.
Sulforaphane suppressed collagen deposition by regulating the MMP-1 and TIMP-1 expression and decreasing the collagen I/III expression ratio in BOO rats and improved bladder compliance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Chong& Wan, Xiang& Gu, Meng& Chen, Yanbo& Cai, Zhikang& Zhou, Juan…[et al.]. 2019. Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1204399
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Chong…[et al.]. Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1204399
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Chong& Wan, Xiang& Gu, Meng& Chen, Yanbo& Cai, Zhikang& Zhou, Juan…[et al.]. Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1204399
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204399
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر