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Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction
Joint Authors
Liu, Chong
Chen, Qi
Zhou, Juan
Wang, Zhong
Wan, Xiang
Gu, Meng
Chen, Yanbo
Cai, Zhikang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Aims.
To investigate the effect of Nrf2 activator sulforaphane (SFN) on bladder compliance and the underlying mechanisms in a rat model of partial bladder outlet obstruction (BOO).
Methods.
Male 8-week-old Sprague-Dawley rats were divided into three groups.
BOO rats were given daily 0.5 mg/kg sulforaphane (BOO+SFN) or vehicle (BOO) intraperitoneally for 4 weeks, while sham-operated rats were treated with vehicle (Sham).
Bladder compliance, histological alteration, and collagen deposition were evaluated.
The expression levels of collagen I, collagen III, MMP-1, and TIMP-1 were measured by immunohistochemistry and western blotting.
Results.
BOO led to a significant decrease in bladder compliance.
The change was partially restored by SFN treatment.
The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment.
Moreover, the increased collagen I/collagen III ratio in the BOO group was reversed by SFN treatment.
Conclusions.
Sulforaphane suppressed collagen deposition by regulating the MMP-1 and TIMP-1 expression and decreasing the collagen I/III expression ratio in BOO rats and improved bladder compliance.
American Psychological Association (APA)
Liu, Chong& Wan, Xiang& Gu, Meng& Chen, Yanbo& Cai, Zhikang& Zhou, Juan…[et al.]. 2019. Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1204399
Modern Language Association (MLA)
Liu, Chong…[et al.]. Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1204399
American Medical Association (AMA)
Liu, Chong& Wan, Xiang& Gu, Meng& Chen, Yanbo& Cai, Zhikang& Zhou, Juan…[et al.]. Effect of Sulforaphane on Bladder Compliance in a Rat Model of Partial Bladder Outlet Obstruction. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1204399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204399