The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility
المؤلفون المشاركون
Wei, Xing
Tian, Sijuan
Zhang, Liping
Yang, Ting
Zhang, Li
Yu, Yang
Li, Yang
Cao, Di
Yang, Xiaofeng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer.
Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017.
We screened the studies and assessed the methodological quality of the included studies and extracted data.
A meta-analysis was performed using RevMan 5.3 and Stata 12.0 software.
Pooled odds ratios and 95% confidence intervals were employed to evaluate the strength of the associations between Toll-like receptor 9 polymorphisms and cervical cancer risk.
A total of 9 studies comprising 3331 cervical cancer patients and 4109 healthy controls met the inclusion criteria.
Of these, 8 studies contained information about G2848A (rs352140) and 4 studies contained information about −1486T/C (rs187084).
Our results revealed that the associations between rs187084 and cervical cancer risk in the dominant model (p=0.002) and heterozygous model (p=0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model.
However, rs352140 was not related to cervical cancer regardless of whether the subgroup analysis was conducted (p>0.05).
In conclusion, there is a significant correlation between rs187084 and cervical cancer risk with the minor C allele increasing the risk of occurrence of cervical cancer.
However, rs352140 is not associated with the occurrence of cervical cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Sijuan& Zhang, Liping& Yang, Ting& Wei, Xing& Zhang, Li& Yu, Yang…[et al.]. 2018. The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204408
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Sijuan…[et al.]. The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204408
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Sijuan& Zhang, Liping& Yang, Ting& Wei, Xing& Zhang, Li& Yu, Yang…[et al.]. The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204408
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204408
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر