The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility
Joint Authors
Wei, Xing
Tian, Sijuan
Zhang, Liping
Yang, Ting
Zhang, Li
Yu, Yang
Li, Yang
Cao, Di
Yang, Xiaofeng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This meta-analysis systematically reviews the association between Toll-like receptor 9 polymorphisms and the risk of cervical cancer.
Case-control studies focused on the association were collected from the PubMed, Web of Science, Cochrane Library, Embase, MEDLINE, CNKI, VIP, and Wanfang databases from inception to July 2017.
We screened the studies and assessed the methodological quality of the included studies and extracted data.
A meta-analysis was performed using RevMan 5.3 and Stata 12.0 software.
Pooled odds ratios and 95% confidence intervals were employed to evaluate the strength of the associations between Toll-like receptor 9 polymorphisms and cervical cancer risk.
A total of 9 studies comprising 3331 cervical cancer patients and 4109 healthy controls met the inclusion criteria.
Of these, 8 studies contained information about G2848A (rs352140) and 4 studies contained information about −1486T/C (rs187084).
Our results revealed that the associations between rs187084 and cervical cancer risk in the dominant model (p=0.002) and heterozygous model (p=0.002) were significant, with 1.30- and 1.32-fold increases in susceptibility, respectively, compared to that in the wild-type model.
However, rs352140 was not related to cervical cancer regardless of whether the subgroup analysis was conducted (p>0.05).
In conclusion, there is a significant correlation between rs187084 and cervical cancer risk with the minor C allele increasing the risk of occurrence of cervical cancer.
However, rs352140 is not associated with the occurrence of cervical cancer.
American Psychological Association (APA)
Tian, Sijuan& Zhang, Liping& Yang, Ting& Wei, Xing& Zhang, Li& Yu, Yang…[et al.]. 2018. The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204408
Modern Language Association (MLA)
Tian, Sijuan…[et al.]. The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility. Mediators of Inflammation No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1204408
American Medical Association (AMA)
Tian, Sijuan& Zhang, Liping& Yang, Ting& Wei, Xing& Zhang, Li& Yu, Yang…[et al.]. The Associations between Toll-Like Receptor 9 Gene Polymorphisms and Cervical Cancer Susceptibility. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1204408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204408