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Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model
المؤلفون المشاركون
Tabaran, Flaviu
Gal, A. F.
Stan, L.
Rugină, D.
Cătoi, A. F.
Andrei, S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Currently, one of the central problems in cancer management is the relapse of disease following conventional treatments, yet few therapeutic agents targeting resistance and tolerance exist.
Propolis is known as a healing agent since ancient times.
Therefore, over time, its curative properties have kept the interest of scientists, thus leading permanently to investigations of its other possible undiscovered effects.
In this context, current experiments were performed to establish the chemopreventive potential of propolis extract (PE) (1.05 mg/kg BW/day) in N-methyl-N-nitrosourea- (MNU-) induced rat mammary tumors.
MNU-inoculated/PE-treated rats had tumors of different physical attributes compared with control rats MNU-inoculated.
The number of developed tumors (mean 49% versus 100%), incidence (mean 49% versus 100%), multiplicity (1.8 versus 3.7 (p<0.001)), tumor volume (mean 10 cm3 versus 16 cm3 (p<0.001)), and weight of the tumor mass (mean 7.42 g versus 9.00 g (p<0.05)) were noted.
The numbers of grade I tumors recorded for MNU-inoculated rats were 24 (Group 1) and 7 (Group 2) for MNU-induced/PE-treated rats.
In the serum of rats MNU-inoculated/PE-treated were found higher levels of antioxidative enzymes (SOD, CAT, and GPx) than in MNU-induced.
Taken together, these data indicate that propolis could be a chemopreventive agent against MNU-induced mammary carcinogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gal, A. F.& Stan, L.& Tabaran, Flaviu& Rugină, D.& Cătoi, A. F.& Andrei, S.. 2020. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204419
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gal, A. F.…[et al.]. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204419
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gal, A. F.& Stan, L.& Tabaran, Flaviu& Rugină, D.& Cătoi, A. F.& Andrei, S.. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204419
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204419
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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