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Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model
Joint Authors
Tabaran, Flaviu
Gal, A. F.
Stan, L.
Rugină, D.
Cătoi, A. F.
Andrei, S.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Currently, one of the central problems in cancer management is the relapse of disease following conventional treatments, yet few therapeutic agents targeting resistance and tolerance exist.
Propolis is known as a healing agent since ancient times.
Therefore, over time, its curative properties have kept the interest of scientists, thus leading permanently to investigations of its other possible undiscovered effects.
In this context, current experiments were performed to establish the chemopreventive potential of propolis extract (PE) (1.05 mg/kg BW/day) in N-methyl-N-nitrosourea- (MNU-) induced rat mammary tumors.
MNU-inoculated/PE-treated rats had tumors of different physical attributes compared with control rats MNU-inoculated.
The number of developed tumors (mean 49% versus 100%), incidence (mean 49% versus 100%), multiplicity (1.8 versus 3.7 (p<0.001)), tumor volume (mean 10 cm3 versus 16 cm3 (p<0.001)), and weight of the tumor mass (mean 7.42 g versus 9.00 g (p<0.05)) were noted.
The numbers of grade I tumors recorded for MNU-inoculated rats were 24 (Group 1) and 7 (Group 2) for MNU-induced/PE-treated rats.
In the serum of rats MNU-inoculated/PE-treated were found higher levels of antioxidative enzymes (SOD, CAT, and GPx) than in MNU-induced.
Taken together, these data indicate that propolis could be a chemopreventive agent against MNU-induced mammary carcinogenesis.
American Psychological Association (APA)
Gal, A. F.& Stan, L.& Tabaran, Flaviu& Rugină, D.& Cătoi, A. F.& Andrei, S.. 2020. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204419
Modern Language Association (MLA)
Gal, A. F.…[et al.]. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204419
American Medical Association (AMA)
Gal, A. F.& Stan, L.& Tabaran, Flaviu& Rugină, D.& Cătoi, A. F.& Andrei, S.. Chemopreventive Effects of Propolis in the MNU-Induced Rat Mammary Tumor Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204419