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TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress
المؤلفون المشاركون
Secchiero, Paola
Tisato, Veronica
Melloni, Elisabetta
Trentini, Alessandro
Bergamini, Carlo M.
Bonaccorsi, Gloria
Zuliani, Giovanni
Passaro, Angelina
Celeghini, Claudio
Cervellati, Carlo
Zauli, Giorgio
Giuseppe, Valacchi
Gallo, Stefania
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-26
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
“Oxinflammation” is a recently coined term that defines the deleterious crosstalk between inflammatory and redox systemic processes, which underlie several diseases.
Oxinflammation could be latently responsible for the predisposition of certain healthy individuals to disease development.
The oxinflammatory pathway has been recently suggested to play a crucial role in regulating the activity of TNF-related apoptosis-inducing ligand (TRAIL), a TNF superfamily member that can mediate multiple signals in physiological and pathological processes.
Therefore, we investigated the associations between TRAIL and key players of vascular redox homeostasis.
Methods.
We measured circulating TRAIL levels relative to praoxonas-1, lipoprotein phospholipase-A2, and ceruloplasmin levels in a cohort of healthy subjects (n=209).
Results.
Multivariate analysis revealed that ceruloplasmin levels were significantly inversely associated with TRAIL levels (r=−0.431, p<0.001).
The observed association retained statistical significance after adjustment for additional confounding factors.
After stratification for high-sensitivity C-reactive protein levels, the inverse association between TRAIL and ceruloplasmin levels remained strong and significant (r=−0.508, p<0.001, R2=0.260) only in the presence of inflammation, confirming the role of inflammation as emerged in in vitro experiments where recombinant TRAIL decreased ceruloplasmin expression levels in TNF-treated PBMC cultures.
Conclusion.
The results indicated that in an inflammatory milieu, TRAIL downregulates ceruloplasmin expression, highlighting a signaling axis involving TRAIL and ceruloplasmin that are linked via inflammation and providing important insights with potential clinical implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tisato, Veronica& Gallo, Stefania& Melloni, Elisabetta& Celeghini, Claudio& Passaro, Angelina& Zauli, Giorgio…[et al.]. 2018. TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tisato, Veronica…[et al.]. TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1204495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tisato, Veronica& Gallo, Stefania& Melloni, Elisabetta& Celeghini, Claudio& Passaro, Angelina& Zauli, Giorgio…[et al.]. TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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