TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress

Joint Authors

Secchiero, Paola
Tisato, Veronica
Melloni, Elisabetta
Trentini, Alessandro
Bergamini, Carlo M.
Bonaccorsi, Gloria
Zuliani, Giovanni
Passaro, Angelina
Celeghini, Claudio
Cervellati, Carlo
Zauli, Giorgio
Giuseppe, Valacchi
Gallo, Stefania

Source

Mediators of Inflammation

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-07-26

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

Objective.

“Oxinflammation” is a recently coined term that defines the deleterious crosstalk between inflammatory and redox systemic processes, which underlie several diseases.

Oxinflammation could be latently responsible for the predisposition of certain healthy individuals to disease development.

The oxinflammatory pathway has been recently suggested to play a crucial role in regulating the activity of TNF-related apoptosis-inducing ligand (TRAIL), a TNF superfamily member that can mediate multiple signals in physiological and pathological processes.

Therefore, we investigated the associations between TRAIL and key players of vascular redox homeostasis.

Methods.

We measured circulating TRAIL levels relative to praoxonas-1, lipoprotein phospholipase-A2, and ceruloplasmin levels in a cohort of healthy subjects (n=209).

Results.

Multivariate analysis revealed that ceruloplasmin levels were significantly inversely associated with TRAIL levels (r=−0.431, p<0.001).

The observed association retained statistical significance after adjustment for additional confounding factors.

After stratification for high-sensitivity C-reactive protein levels, the inverse association between TRAIL and ceruloplasmin levels remained strong and significant (r=−0.508, p<0.001, R2=0.260) only in the presence of inflammation, confirming the role of inflammation as emerged in in vitro experiments where recombinant TRAIL decreased ceruloplasmin expression levels in TNF-treated PBMC cultures.

Conclusion.

The results indicated that in an inflammatory milieu, TRAIL downregulates ceruloplasmin expression, highlighting a signaling axis involving TRAIL and ceruloplasmin that are linked via inflammation and providing important insights with potential clinical implications.

American Psychological Association (APA)

Tisato, Veronica& Gallo, Stefania& Melloni, Elisabetta& Celeghini, Claudio& Passaro, Angelina& Zauli, Giorgio…[et al.]. 2018. TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress. Mediators of Inflammation،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204495

Modern Language Association (MLA)

Tisato, Veronica…[et al.]. TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress. Mediators of Inflammation No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1204495

American Medical Association (AMA)

Tisato, Veronica& Gallo, Stefania& Melloni, Elisabetta& Celeghini, Claudio& Passaro, Angelina& Zauli, Giorgio…[et al.]. TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress. Mediators of Inflammation. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1204495

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1204495