Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women
المؤلفون المشاركون
Olek, Robert Antoni
Samulak, Joanna Jolanta
Sawicka, Angelika Katarzyna
Hartmane, Dace
Grinberga, Solveiga
Pugovics, Osvalds
Lysiak-Szydlowska, Wieslawa
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-09-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Increased plasma trimethylamine N-oxide (TMAO) levels have been associated with cardiovascular diseases (CVD).
L-carnitine induces TMAO elevation in human blood, and thus, it has been suggested as developing atherosclerosis.
The aim of this study was to determine the relation between selected markers of oxidative stress and plasma TMAO concentration induced by L-carnitine supplementation for 24 weeks in healthy aged women.
Twenty aged women were supplemented during 24 weeks with either 1500 mg L-carnitine-L-tartrate (n=11) or isonitrogenous placebo (n=9) per day.
Fasting blood samples were taken from antecubital vein.
L-carnitine supplementation induced an increase in TMAO, but not in γ-butyrobetaine (GBB).
Moreover, there were no significant changes in serum ox-LDL, myeloperoxidase, protein carbonyls, homocysteine, and uric acid concentrations due to supplementation.
Significant reduction in white blood cell counts has been observed following 24-week supplementation, but not attributable to L-carnitine.
Our results in healthy aged women indicated no relation between TMAO and any determined marker of oxidative stress over the period of 24 weeks.
At the same time, plasma GBB levels were not affected by L-carnitine supplementation.
Further clinical studies of plasma GBB level as a prognostic marker are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Olek, Robert Antoni& Samulak, Joanna Jolanta& Sawicka, Angelika Katarzyna& Hartmane, Dace& Grinberga, Solveiga& Pugovics, Osvalds…[et al.]. 2019. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1204507
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Olek, Robert Antoni…[et al.]. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1204507
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Olek, Robert Antoni& Samulak, Joanna Jolanta& Sawicka, Angelika Katarzyna& Hartmane, Dace& Grinberga, Solveiga& Pugovics, Osvalds…[et al.]. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1204507
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204507
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر