Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women
Joint Authors
Olek, Robert Antoni
Samulak, Joanna Jolanta
Sawicka, Angelika Katarzyna
Hartmane, Dace
Grinberga, Solveiga
Pugovics, Osvalds
Lysiak-Szydlowska, Wieslawa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Increased plasma trimethylamine N-oxide (TMAO) levels have been associated with cardiovascular diseases (CVD).
L-carnitine induces TMAO elevation in human blood, and thus, it has been suggested as developing atherosclerosis.
The aim of this study was to determine the relation between selected markers of oxidative stress and plasma TMAO concentration induced by L-carnitine supplementation for 24 weeks in healthy aged women.
Twenty aged women were supplemented during 24 weeks with either 1500 mg L-carnitine-L-tartrate (n=11) or isonitrogenous placebo (n=9) per day.
Fasting blood samples were taken from antecubital vein.
L-carnitine supplementation induced an increase in TMAO, but not in γ-butyrobetaine (GBB).
Moreover, there were no significant changes in serum ox-LDL, myeloperoxidase, protein carbonyls, homocysteine, and uric acid concentrations due to supplementation.
Significant reduction in white blood cell counts has been observed following 24-week supplementation, but not attributable to L-carnitine.
Our results in healthy aged women indicated no relation between TMAO and any determined marker of oxidative stress over the period of 24 weeks.
At the same time, plasma GBB levels were not affected by L-carnitine supplementation.
Further clinical studies of plasma GBB level as a prognostic marker are needed.
American Psychological Association (APA)
Olek, Robert Antoni& Samulak, Joanna Jolanta& Sawicka, Angelika Katarzyna& Hartmane, Dace& Grinberga, Solveiga& Pugovics, Osvalds…[et al.]. 2019. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1204507
Modern Language Association (MLA)
Olek, Robert Antoni…[et al.]. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1204507
American Medical Association (AMA)
Olek, Robert Antoni& Samulak, Joanna Jolanta& Sawicka, Angelika Katarzyna& Hartmane, Dace& Grinberga, Solveiga& Pugovics, Osvalds…[et al.]. Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1204507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204507