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Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats
المؤلف
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Monolluma quadrangula is a succulent bush traditionally used to treat diabetes and peptic ulcer.
The present study aimed to investigate the effect of M.
quadrangula hydroethanolic extract on glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, lipid profile, and adiponectin expression in type 2 diabetic rats.
In addition, the study evaluated the antioxidant and anti-inflammatory activities of the M.
quadrangula extract.
Type 2 diabetes was induced by feeding rats a high-fat diet (HFD) for 8 weeks followed by 30 mg/kg streptozotocin (STZ).
Diabetic rats received 300 or 600 mg/kg M.
quadrangula extract for 4 weeks.
HFD/STZ diabetic rats showed impaired glucose tolerance, reduced insulin secretion, and insulin resistance.
HFD and STZ induced a significant increase in serum cholesterol, triglycerides and proinflammatory cytokines, and liver lipid peroxidation.
Treatment with M.
quadrangula extract ameliorated these metabolic disturbances and increased liver glycogen, hexokinase activity, and antioxidants.
M.
quadrangula declined the activity of liver glucose-6-phosphatase and fructose-1,6-biphosphatase.
In addition, M.
quadrangula extract increased serum adiponectin levels and hepatic adiponectin expression in HFD/STZ diabetic rats.
In conclusion, M.
quadrangula exerts antidiabetic effect mediated via ameliorating glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, and antioxidant defenses.
Increased adiponectin levels and expression seems to mediate, at least in part, the antidiabetic effect of M.
quadrangula.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bin-Jumah, May. 2019. Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bin-Jumah, May. Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bin-Jumah, May. Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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