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Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats
Author
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Monolluma quadrangula is a succulent bush traditionally used to treat diabetes and peptic ulcer.
The present study aimed to investigate the effect of M.
quadrangula hydroethanolic extract on glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, lipid profile, and adiponectin expression in type 2 diabetic rats.
In addition, the study evaluated the antioxidant and anti-inflammatory activities of the M.
quadrangula extract.
Type 2 diabetes was induced by feeding rats a high-fat diet (HFD) for 8 weeks followed by 30 mg/kg streptozotocin (STZ).
Diabetic rats received 300 or 600 mg/kg M.
quadrangula extract for 4 weeks.
HFD/STZ diabetic rats showed impaired glucose tolerance, reduced insulin secretion, and insulin resistance.
HFD and STZ induced a significant increase in serum cholesterol, triglycerides and proinflammatory cytokines, and liver lipid peroxidation.
Treatment with M.
quadrangula extract ameliorated these metabolic disturbances and increased liver glycogen, hexokinase activity, and antioxidants.
M.
quadrangula declined the activity of liver glucose-6-phosphatase and fructose-1,6-biphosphatase.
In addition, M.
quadrangula extract increased serum adiponectin levels and hepatic adiponectin expression in HFD/STZ diabetic rats.
In conclusion, M.
quadrangula exerts antidiabetic effect mediated via ameliorating glucose tolerance, insulin sensitivity, glucose metabolizing enzymes, and antioxidant defenses.
Increased adiponectin levels and expression seems to mediate, at least in part, the antidiabetic effect of M.
quadrangula.
American Psychological Association (APA)
Bin-Jumah, May. 2019. Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204524
Modern Language Association (MLA)
Bin-Jumah, May. Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204524
American Medical Association (AMA)
Bin-Jumah, May. Antidiabetic Effect of Monolluma quadrangula Is Mediated via Modulation of Glucose Metabolizing Enzymes, Antioxidant Defenses, and Adiponectin in Type 2 Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204524
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204524