Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma

المؤلفون المشاركون

Shang, Yan
He, Yanan
Wang, Kun
Wang, Muyun
Gao, Wei
Yin, Huiming
Li, Qiang

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-11-20

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الأحياء

الملخص EN

Airway remodeling played a vital role in the development of asthma, and airway smooth muscle (ASM) mass was its hallmark.

However, few strategies targeting ASM remodeling were developed in treating asthma.

Nur77 was the transcription factor nuclear receptor involved in the pathogenesis of several lung diseases.

Nur77 distribution and expression were determined in an HDM-mediated allergic asthma model.

Its effect on airway hyperresponsiveness (AHR), chronic inflammation, and ASM remodeling in asthmatic mice was evaluated using a lentivirus-mediated shRNA.

Possible mechanisms were explored by examining Nur77 actions and its underlying pathways in primary human AMC cells (ASMCs).

In this study, we reported that Nur77 expression was mainly distributed along ASM and increased in lungs of HDM-challenged mice.

Nur77 depletion by lentivirus-mediated shRNA ameliorated AHR, chronic inflammation, goblet cell hyperplasia, and airway remodeling in the asthmatic mouse model.

By means of primary human ASMC, we discovered that Nur77 upregulation by HDM stimulation promoted cell proliferation and ROS production, as well as reduced antioxidant gene expression.

These alterations might associate with MFN2/MAPK/AKT pathways.

These findings broadened our understanding of airway remodeling and ASMC proliferation, which might provide a novel therapeutic target for asthma patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Kun& Wang, Muyun& Shang, Yan& He, Yanan& Li, Qiang& Gao, Wei…[et al.]. 2020. Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204545

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Kun…[et al.]. Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204545

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Kun& Wang, Muyun& Shang, Yan& He, Yanan& Li, Qiang& Gao, Wei…[et al.]. Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204545

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1204545