Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma
Joint Authors
Shang, Yan
He, Yanan
Wang, Kun
Wang, Muyun
Gao, Wei
Yin, Huiming
Li, Qiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-20
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Airway remodeling played a vital role in the development of asthma, and airway smooth muscle (ASM) mass was its hallmark.
However, few strategies targeting ASM remodeling were developed in treating asthma.
Nur77 was the transcription factor nuclear receptor involved in the pathogenesis of several lung diseases.
Nur77 distribution and expression were determined in an HDM-mediated allergic asthma model.
Its effect on airway hyperresponsiveness (AHR), chronic inflammation, and ASM remodeling in asthmatic mice was evaluated using a lentivirus-mediated shRNA.
Possible mechanisms were explored by examining Nur77 actions and its underlying pathways in primary human AMC cells (ASMCs).
In this study, we reported that Nur77 expression was mainly distributed along ASM and increased in lungs of HDM-challenged mice.
Nur77 depletion by lentivirus-mediated shRNA ameliorated AHR, chronic inflammation, goblet cell hyperplasia, and airway remodeling in the asthmatic mouse model.
By means of primary human ASMC, we discovered that Nur77 upregulation by HDM stimulation promoted cell proliferation and ROS production, as well as reduced antioxidant gene expression.
These alterations might associate with MFN2/MAPK/AKT pathways.
These findings broadened our understanding of airway remodeling and ASMC proliferation, which might provide a novel therapeutic target for asthma patients.
American Psychological Association (APA)
Wang, Kun& Wang, Muyun& Shang, Yan& He, Yanan& Li, Qiang& Gao, Wei…[et al.]. 2020. Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204545
Modern Language Association (MLA)
Wang, Kun…[et al.]. Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1204545
American Medical Association (AMA)
Wang, Kun& Wang, Muyun& Shang, Yan& He, Yanan& Li, Qiang& Gao, Wei…[et al.]. Regulatory Effects of Nur77 on Airway Remodeling and ASMC Proliferation in House Dust Mite-Induced Asthma. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1204545
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204545