Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model
المؤلفون المشاركون
Chavarría, Anahí
Navarro, L.
Ugalde-Muñiz, Perla
Fetter-Pruneda, Ingrid
García, Esperanza
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-13
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration.
This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in the physiopathological mechanisms of Parkinson’s disease.
Two different models of systemic inflammation were employed to explore this hypothesis: a single administration of lipopolysaccharide (sLPS; 5 mg/kg) and chronic exposure to low doses (mLPS; 100 μg/kg twice a week for three months).
After three months, both groups were challenged with MPTP.
With the sLPS administration, Iba1 staining increased in the striatum and substantia nigra, and the cell viability lowered in the striatum of these mice.
mLPS alone had more impact on the proinflammatory profile of the brain, steadily increasing TNFα levels, activating microglia, reducing BDNF, cell viability, and dopamine levels, leading to a damage profile similar to the MPTP model per se.
Interestingly, mLPS increased MAO-B activity possibly conferring susceptibility to MPTP damage.
mLPS, along with MPTP administration, exacerbated the neurotoxic effect.
This effect seemed to be coordinated by microglia since minocycline administration prevented brain TNFα increase.
Coadministration of sLPS with MPTP only facilitated damage induced by MPTP without significant change in the inflammatory profile.
These results indicate that chronic systemic inflammation increased susceptibility to MPTP toxic effect and is an adequate model for studying the impact of systemic inflammation in Parkinson’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ugalde-Muñiz, Perla& Fetter-Pruneda, Ingrid& Navarro, L.& García, Esperanza& Chavarría, Anahí. 2020. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204621
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ugalde-Muñiz, Perla…[et al.]. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1204621
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ugalde-Muñiz, Perla& Fetter-Pruneda, Ingrid& Navarro, L.& García, Esperanza& Chavarría, Anahí. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204621
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204621
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر