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Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model
Joint Authors
Chavarría, Anahí
Navarro, L.
Ugalde-Muñiz, Perla
Fetter-Pruneda, Ingrid
García, Esperanza
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-13
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration.
This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in the physiopathological mechanisms of Parkinson’s disease.
Two different models of systemic inflammation were employed to explore this hypothesis: a single administration of lipopolysaccharide (sLPS; 5 mg/kg) and chronic exposure to low doses (mLPS; 100 μg/kg twice a week for three months).
After three months, both groups were challenged with MPTP.
With the sLPS administration, Iba1 staining increased in the striatum and substantia nigra, and the cell viability lowered in the striatum of these mice.
mLPS alone had more impact on the proinflammatory profile of the brain, steadily increasing TNFα levels, activating microglia, reducing BDNF, cell viability, and dopamine levels, leading to a damage profile similar to the MPTP model per se.
Interestingly, mLPS increased MAO-B activity possibly conferring susceptibility to MPTP damage.
mLPS, along with MPTP administration, exacerbated the neurotoxic effect.
This effect seemed to be coordinated by microglia since minocycline administration prevented brain TNFα increase.
Coadministration of sLPS with MPTP only facilitated damage induced by MPTP without significant change in the inflammatory profile.
These results indicate that chronic systemic inflammation increased susceptibility to MPTP toxic effect and is an adequate model for studying the impact of systemic inflammation in Parkinson’s disease.
American Psychological Association (APA)
Ugalde-Muñiz, Perla& Fetter-Pruneda, Ingrid& Navarro, L.& García, Esperanza& Chavarría, Anahí. 2020. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204621
Modern Language Association (MLA)
Ugalde-Muñiz, Perla…[et al.]. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1204621
American Medical Association (AMA)
Ugalde-Muñiz, Perla& Fetter-Pruneda, Ingrid& Navarro, L.& García, Esperanza& Chavarría, Anahí. Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson’s Disease Model. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1204621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204621