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Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes
المؤلفون المشاركون
Wu, Hongwei
Zhang, Jingjing
Zhou, Rui
Xiang, Changpei
Jia, Qiang
Yang, Hongjun
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-26
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
As a serious complication of diabetes, nonhealing skin ulcer leads to high mortality and disability in diabetic patients.
However, limited therapy is available in managing diabetic wounds.
In this study, RNA-seq technology was used to systematically investigate the effect of Huangbai (HB) liniment, a traditional Chinese medicine, on the streptozotocin- (STZ-) induced diabetic wound.
HB liniment significantly accelerated the wound closure and enhanced the generation of extracellular matrix in diabetic rats, and oxidative stress was identified to play a vital role in HB-mediated wound healing.
Importantly, HB liniment activated nuclear factor erythroid-derived 2-like 2 (Nrf2) and its downstream antioxidant genes (e.g., genes involved in glutathione system, thioredoxin system, and GAPDH generation as well as other antioxidant genes), which inhibited oxidative damage and apoptosis.
By associating drug targets of HB liniment with Nrf2 and its downstream genes, 54 components in HB liniment were screened out, and the majority was from Cortex Phellodendri and Forsythia suspensa.
Additionally, HB liniment enhanced TGF-β1 and reduced MMP9 level, accelerating wound healing in diabetes.
The in vitro experiment showed HB facilitated cell proliferation and inhibited oxidative damage in high glucose-induced HaCaT cells.
Our findings provided the experimental evidence for the treatment of diabetic wound with HB, clarified the potential mechanism of HB, and improved our understanding of diabetic wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Jingjing& Zhou, Rui& Xiang, Changpei& Jia, Qiang& Wu, Hongwei& Yang, Hongjun. 2020. Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1204662
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Jingjing…[et al.]. Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1204662
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Jingjing& Zhou, Rui& Xiang, Changpei& Jia, Qiang& Wu, Hongwei& Yang, Hongjun. Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1204662
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204662
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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