Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes
Joint Authors
Wu, Hongwei
Zhang, Jingjing
Zhou, Rui
Xiang, Changpei
Jia, Qiang
Yang, Hongjun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-26
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
As a serious complication of diabetes, nonhealing skin ulcer leads to high mortality and disability in diabetic patients.
However, limited therapy is available in managing diabetic wounds.
In this study, RNA-seq technology was used to systematically investigate the effect of Huangbai (HB) liniment, a traditional Chinese medicine, on the streptozotocin- (STZ-) induced diabetic wound.
HB liniment significantly accelerated the wound closure and enhanced the generation of extracellular matrix in diabetic rats, and oxidative stress was identified to play a vital role in HB-mediated wound healing.
Importantly, HB liniment activated nuclear factor erythroid-derived 2-like 2 (Nrf2) and its downstream antioxidant genes (e.g., genes involved in glutathione system, thioredoxin system, and GAPDH generation as well as other antioxidant genes), which inhibited oxidative damage and apoptosis.
By associating drug targets of HB liniment with Nrf2 and its downstream genes, 54 components in HB liniment were screened out, and the majority was from Cortex Phellodendri and Forsythia suspensa.
Additionally, HB liniment enhanced TGF-β1 and reduced MMP9 level, accelerating wound healing in diabetes.
The in vitro experiment showed HB facilitated cell proliferation and inhibited oxidative damage in high glucose-induced HaCaT cells.
Our findings provided the experimental evidence for the treatment of diabetic wound with HB, clarified the potential mechanism of HB, and improved our understanding of diabetic wound healing.
American Psychological Association (APA)
Zhang, Jingjing& Zhou, Rui& Xiang, Changpei& Jia, Qiang& Wu, Hongwei& Yang, Hongjun. 2020. Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1204662
Modern Language Association (MLA)
Zhang, Jingjing…[et al.]. Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1204662
American Medical Association (AMA)
Zhang, Jingjing& Zhou, Rui& Xiang, Changpei& Jia, Qiang& Wu, Hongwei& Yang, Hongjun. Huangbai Liniment Accelerated Wound Healing by Activating Nrf2 Signaling in Diabetes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1204662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204662