Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia
المؤلفون المشاركون
Wang, Menglong
Meng, Guannan
Chen, Hui
Wang, Zhuo
Jiang, Hong
Wang, Zhenya
Li, Shuyan
Lai, Huanzhu
Zhou, Liping
Lai, Yanqiu
Zhou, Xiaoya
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Endothelin-1 (ET-1) is synthesized primarily by endothelial cells.
ET-1 administration in vivo enhances the cardiac sympathetic afferent reflex and sympathetic activity.
Previous studies have shown that sympathetic hyperactivity promotes malignant ventricular arrhythmia (VA).
The aim of this study was to investigate whether ET-1 could activate the left stellate ganglion (LSG) and promote malignant VA.
Twelve male beagle dogs who received local microinjections of saline (control, n=6) and ET-1 into the LSG (n=6) were included.
The ventricular effective refractory period (ERP), LSG function, and LSG activity were measured at different time points.
VA was continuously recorded for 1 h after left anterior descending occlusion (LADO), and LSG tissues were then collected for molecular detection.
Compared to that of the control group, local ET-1 microinjection significantly decreased the ERP and increased the occurrence of VA.
In addition, local microinjection of ET-1 increased the function and activity of the LSG in the normal and ischemic hearts.
The expression levels of proinflammatory cytokines and the protein expression of c-fos and nerve growth factor (NGF) in the LSG were also increased.
More importantly, endothelin A receptor (ETA-R) expression was found in the LSG, and its signaling was significantly activated in the ET-1 group.
LSG activation induced by local ET-1 microinjection aggravates LADO-induced VA.
Activated ETA-R signaling and the upregulation of proinflammatory cytokines in the LSG may be responsible for these effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhenya& Li, Shuyan& Lai, Huanzhu& Zhou, Liping& Meng, Guannan& Wang, Menglong…[et al.]. 2019. Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204684
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhenya…[et al.]. Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204684
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhenya& Li, Shuyan& Lai, Huanzhu& Zhou, Liping& Meng, Guannan& Wang, Menglong…[et al.]. Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204684
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204684
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر