Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia
Joint Authors
Wang, Menglong
Meng, Guannan
Chen, Hui
Wang, Zhuo
Jiang, Hong
Wang, Zhenya
Li, Shuyan
Lai, Huanzhu
Zhou, Liping
Lai, Yanqiu
Zhou, Xiaoya
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Endothelin-1 (ET-1) is synthesized primarily by endothelial cells.
ET-1 administration in vivo enhances the cardiac sympathetic afferent reflex and sympathetic activity.
Previous studies have shown that sympathetic hyperactivity promotes malignant ventricular arrhythmia (VA).
The aim of this study was to investigate whether ET-1 could activate the left stellate ganglion (LSG) and promote malignant VA.
Twelve male beagle dogs who received local microinjections of saline (control, n=6) and ET-1 into the LSG (n=6) were included.
The ventricular effective refractory period (ERP), LSG function, and LSG activity were measured at different time points.
VA was continuously recorded for 1 h after left anterior descending occlusion (LADO), and LSG tissues were then collected for molecular detection.
Compared to that of the control group, local ET-1 microinjection significantly decreased the ERP and increased the occurrence of VA.
In addition, local microinjection of ET-1 increased the function and activity of the LSG in the normal and ischemic hearts.
The expression levels of proinflammatory cytokines and the protein expression of c-fos and nerve growth factor (NGF) in the LSG were also increased.
More importantly, endothelin A receptor (ETA-R) expression was found in the LSG, and its signaling was significantly activated in the ET-1 group.
LSG activation induced by local ET-1 microinjection aggravates LADO-induced VA.
Activated ETA-R signaling and the upregulation of proinflammatory cytokines in the LSG may be responsible for these effects.
American Psychological Association (APA)
Wang, Zhenya& Li, Shuyan& Lai, Huanzhu& Zhou, Liping& Meng, Guannan& Wang, Menglong…[et al.]. 2019. Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204684
Modern Language Association (MLA)
Wang, Zhenya…[et al.]. Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1204684
American Medical Association (AMA)
Wang, Zhenya& Li, Shuyan& Lai, Huanzhu& Zhou, Liping& Meng, Guannan& Wang, Menglong…[et al.]. Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1204684
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204684