Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation
المؤلفون المشاركون
Alhomida, Abdullah S.
kandan, P. Veeramani
Balupillai, Agilan
Kanimozhi, G.
Khan, Haseeb A.
Prasad, Nagarajan Rajendra
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In the present study, we investigated the potential of opuntiol, isolated from Opuntia ficus-indica, against UVA radiation-mediated inflammation and skin photoaging in experimental animals.
The skin-shaved experimental mouse was subjected to UVA exposure at the dosage of 10 J/cm2 per day for ten consecutive days (cumulative UVA dose: 100 J/cm2).
Opuntiol (50 mg/kg b.wt.) was topically applied one hour before each UVA exposure.
UVA (100 J/cm2) exposure induces epidermal hyperplasia and collagen disarrangement which leads to the photoaging-associated molecular changes in the mouse skin.
Opuntiol pretreatment prevented UVA-linked clinical macroscopic skin lesions and histological changes in the mouse skin.
Further, opuntiol prevents UVA-linked dermal collagen fiber loss in the mouse skin.
Short-term UVA radiation (100 J/cm2) activates MAPKs through AP-1 and NF-κB p65 transcriptional pathways and subsequently induces the expression of inflammatory proteins and matrix-degrading proteinases in the mouse skin.
Interestingly, opuntiol pretreatment inhibited UVA-induced activation of iNOS, VEGF, TNF-α, and COX-2 proteins and consequent activation of MMP-2, MMP-9, and MMP-12 in the mouse skin.
Moreover, opuntiol was found to prevent collagen I and III breakdown in UVA radiation-exposed mouse skin.
Thus, opuntiol protects mouse skin from UVA radiation-associated photoaging responses through inhibiting inflammatory responses, MAPK activation, and degradation of matrix collagen molecules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
kandan, P. Veeramani& Balupillai, Agilan& Kanimozhi, G.& Khan, Haseeb A.& Alhomida, Abdullah S.& Prasad, Nagarajan Rajendra. 2020. Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204785
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
kandan, P. Veeramani…[et al.]. Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204785
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
kandan, P. Veeramani& Balupillai, Agilan& Kanimozhi, G.& Khan, Haseeb A.& Alhomida, Abdullah S.& Prasad, Nagarajan Rajendra. Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204785
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204785
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر