Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation
Joint Authors
Alhomida, Abdullah S.
kandan, P. Veeramani
Balupillai, Agilan
Kanimozhi, G.
Khan, Haseeb A.
Prasad, Nagarajan Rajendra
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In the present study, we investigated the potential of opuntiol, isolated from Opuntia ficus-indica, against UVA radiation-mediated inflammation and skin photoaging in experimental animals.
The skin-shaved experimental mouse was subjected to UVA exposure at the dosage of 10 J/cm2 per day for ten consecutive days (cumulative UVA dose: 100 J/cm2).
Opuntiol (50 mg/kg b.wt.) was topically applied one hour before each UVA exposure.
UVA (100 J/cm2) exposure induces epidermal hyperplasia and collagen disarrangement which leads to the photoaging-associated molecular changes in the mouse skin.
Opuntiol pretreatment prevented UVA-linked clinical macroscopic skin lesions and histological changes in the mouse skin.
Further, opuntiol prevents UVA-linked dermal collagen fiber loss in the mouse skin.
Short-term UVA radiation (100 J/cm2) activates MAPKs through AP-1 and NF-κB p65 transcriptional pathways and subsequently induces the expression of inflammatory proteins and matrix-degrading proteinases in the mouse skin.
Interestingly, opuntiol pretreatment inhibited UVA-induced activation of iNOS, VEGF, TNF-α, and COX-2 proteins and consequent activation of MMP-2, MMP-9, and MMP-12 in the mouse skin.
Moreover, opuntiol was found to prevent collagen I and III breakdown in UVA radiation-exposed mouse skin.
Thus, opuntiol protects mouse skin from UVA radiation-associated photoaging responses through inhibiting inflammatory responses, MAPK activation, and degradation of matrix collagen molecules.
American Psychological Association (APA)
kandan, P. Veeramani& Balupillai, Agilan& Kanimozhi, G.& Khan, Haseeb A.& Alhomida, Abdullah S.& Prasad, Nagarajan Rajendra. 2020. Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204785
Modern Language Association (MLA)
kandan, P. Veeramani…[et al.]. Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204785
American Medical Association (AMA)
kandan, P. Veeramani& Balupillai, Agilan& Kanimozhi, G.& Khan, Haseeb A.& Alhomida, Abdullah S.& Prasad, Nagarajan Rajendra. Opuntiol Prevents Photoaging of Mouse Skin via Blocking Inflammatory Responses and Collagen Degradation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204785
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204785