OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome

المؤلفون المشاركون

Soto, María Elena
Guarner Lans, Verónica
Pérez-Torres, Israel
Castrejón-Tellez, Vicente
Manzano-Pech, Linaloe
Díaz-Galindo, Jorge A.
Vásquez, Xicoténcatl
Gamboa, Ricardo
Huesca, Claudia
Fuentevilla-Alvárez, Giovanny

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-17، 17ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-03-24

دولة النشر

مصر

عدد الصفحات

17

التخصصات الرئيسية

الأحياء

الملخص EN

Patients with the Loeys-Dietz syndrome (LDS) have mutations in the TGF-βR1, TGF-βR2, and SMAD3 genes.

However, little is known about the redox homeostasis in the thoracic aortic aneurysms (TAA) they develop.

Here, we evaluate the oxidant/antioxidant profile in the TAA tissue from LDS patients and compare it with that in nondamaged aortic tissue from control (C) subjects.

We evaluate the enzymatic activities of glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD) isoforms, and thioredoxin reductase (TrxR).

We also analyze some antioxidants from a nonenzymatic system such as selenium (Se), glutathione (GSH), and total antioxidant capacity (TAC).

Oxidative stress markers such as lipid peroxidation and carbonylation, as well as xanthine oxidase (ORX) and nuclear factor erythroid 2-related factor 2 (Nrf2) expressions, were also evaluated.

TAA from LDS patients showed a decrease in GSH, Se, TAC, GPx, GST, CAT, and TrxR.

The SOD activity and ORX expressions were increased, but the Nrf2 expression was decreased.

The results suggest that the redox homeostasis is altered in the TAA from LDS patients, favoring ROS overproduction that contributes to the decrease in GSH and TAC and leads to LPO and carbonylation.

The decrease in Se and Nrf2 alters the activity and/or expression of some antioxidant enzymes, thus favoring a positive feedback oxidative background that contributes to the TAA formation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Soto, María Elena& Manzano-Pech, Linaloe& Guarner Lans, Verónica& Díaz-Galindo, Jorge A.& Vásquez, Xicoténcatl& Castrejón-Tellez, Vicente…[et al.]. 2020. OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204834

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Soto, María Elena…[et al.]. OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1204834

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Soto, María Elena& Manzano-Pech, Linaloe& Guarner Lans, Verónica& Díaz-Galindo, Jorge A.& Vásquez, Xicoténcatl& Castrejón-Tellez, Vicente…[et al.]. OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204834

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1204834