OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome
Joint Authors
Soto, María Elena
Guarner Lans, Verónica
Pérez-Torres, Israel
Castrejón-Tellez, Vicente
Manzano-Pech, Linaloe
Díaz-Galindo, Jorge A.
Vásquez, Xicoténcatl
Gamboa, Ricardo
Huesca, Claudia
Fuentevilla-Alvárez, Giovanny
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Patients with the Loeys-Dietz syndrome (LDS) have mutations in the TGF-βR1, TGF-βR2, and SMAD3 genes.
However, little is known about the redox homeostasis in the thoracic aortic aneurysms (TAA) they develop.
Here, we evaluate the oxidant/antioxidant profile in the TAA tissue from LDS patients and compare it with that in nondamaged aortic tissue from control (C) subjects.
We evaluate the enzymatic activities of glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase (GR), catalase (CAT), superoxide dismutase (SOD) isoforms, and thioredoxin reductase (TrxR).
We also analyze some antioxidants from a nonenzymatic system such as selenium (Se), glutathione (GSH), and total antioxidant capacity (TAC).
Oxidative stress markers such as lipid peroxidation and carbonylation, as well as xanthine oxidase (ORX) and nuclear factor erythroid 2-related factor 2 (Nrf2) expressions, were also evaluated.
TAA from LDS patients showed a decrease in GSH, Se, TAC, GPx, GST, CAT, and TrxR.
The SOD activity and ORX expressions were increased, but the Nrf2 expression was decreased.
The results suggest that the redox homeostasis is altered in the TAA from LDS patients, favoring ROS overproduction that contributes to the decrease in GSH and TAC and leads to LPO and carbonylation.
The decrease in Se and Nrf2 alters the activity and/or expression of some antioxidant enzymes, thus favoring a positive feedback oxidative background that contributes to the TAA formation.
American Psychological Association (APA)
Soto, María Elena& Manzano-Pech, Linaloe& Guarner Lans, Verónica& Díaz-Galindo, Jorge A.& Vásquez, Xicoténcatl& Castrejón-Tellez, Vicente…[et al.]. 2020. OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204834
Modern Language Association (MLA)
Soto, María Elena…[et al.]. OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-17.
https://search.emarefa.net/detail/BIM-1204834
American Medical Association (AMA)
Soto, María Elena& Manzano-Pech, Linaloe& Guarner Lans, Verónica& Díaz-Galindo, Jorge A.& Vásquez, Xicoténcatl& Castrejón-Tellez, Vicente…[et al.]. OxidantAntioxidant Profile in the Thoracic Aneurysm of Patients with the Loeys-Dietz Syndrome. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-17.
https://search.emarefa.net/detail/BIM-1204834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204834