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Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress
المؤلفون المشاركون
Valvassori, Samira S.
Dal-Pizzol, Felipe
Saba, Sumbal
Rafique, Jamal
Frizon, Tiago E. A.
Cararo, José H.
Dal-Pont, Gustavo C.
Michels, Monique
Braga, Hugo C.
Pimentel, Tairine
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Herein, we report the synthesis of novel selenocyanates and assessment of their effect on the oxidative challenge elicited by hydrogen peroxide (H2O2) in cultured mouse neurons.
First, α-methylene-β-hydroxy esters were prepared as precursors of allylic bromides.
A reaction involving the generated bromides and sodium selenocyanate was conducted to produce the desired selenocyanates (3a-f).
We next prepared cultures of neurons from 7-day-old mice (n=36).
H2O2 (10-5 M) was added into the culture flasks as an oxidative stress inducer, alone or combined with one of each designed compounds.
(PhSe)2 was used as a positive control.
It was carried out assessment of lipid (thiobarbituric acid reactive species, 4-hydroxy-2′-nonenal, 8-isoprostane), DNA (8-hydroxy-2′-deoxyguanosine), and protein (carbonyl) modification parameters.
Finally, catalase and superoxide dismutase activities were also evaluated.
Among the compounds, 3b, 3d, and 3f exhibited the most pronounced pattern of antioxidant activity, similar to (PhSe)2.
These novel aromatic selenocyanates could be promising to be tried in most sophisticated in vitro studies or even at the preclinical level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Frizon, Tiago E. A.& Cararo, José H.& Saba, Sumbal& Dal-Pont, Gustavo C.& Michels, Monique& Braga, Hugo C.…[et al.]. 2020. Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204855
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Frizon, Tiago E. A.…[et al.]. Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1204855
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Frizon, Tiago E. A.& Cararo, José H.& Saba, Sumbal& Dal-Pont, Gustavo C.& Michels, Monique& Braga, Hugo C.…[et al.]. Synthesis of Novel Selenocyanates and Evaluation of Their Effect in Cultured Mouse Neurons Submitted to Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1204855
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204855
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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