Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes
المؤلفون المشاركون
Iheagwam, Franklyn Nonso
Israel, Emmanuel Nsedu
De Campos, Opeyemi Christianah
Ogunlana, Olubanke Olujoke
Chinedu, Shalom Nwodo
Kayode, Kazeem Oyindamola
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-10
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This study was carried out to assess the in vitro antioxidant, anti-inflammatory and antidiabetic effects of Nauclea latifolia (Sm.) leaf extracts.
Ethanolic (NLE) and aqueous (NLA) extract of N.
latifolia leaves were prepared and assessed for their anti-inflammatory activity, antioxidant potential, α-amylase and α-glucosidase inhibitory activities, and the mechanism of enzyme inhibition in vitro using standard established methods.
From the results, phytochemicals such as flavonoids, phenolics, glycosides, and tannins were detected in both extracts of N.
latifolia with NLE having a significantly (p<0.05) higher phytochemical content.
NLE displayed significantly (p<0.05) better total antioxidant capacity, reducing power, 2,2-diphenyl-2-picrylhydrazyl, and hydrogen peroxide radical scavenging activities.
For anti-inflammatory activities, 70.54±2.45% albumin denaturation inhibition was observed for NLE while 68.05±1.03% was recorded for NLA.
Likewise, 16.07±1.60 and 14.08±1.76% were obtained against hypotonic solution and heat-induced erythrocyte haemolysis, respectively, for NLE while 20.59±4.60 and 24.07±1.60% were respective NLA values.
NLE (IC50: 4.20±0.18 and 1.19±0.11 mg/mL) and NLA (IC50: 11.21±0.35 and 2.64±0.48 mg/mL) α-glucosidase and α-amylase inhibitory activities were dose-dependent with uncompetitive and competitive inhibition elicited, respectively, by the extracts.
A significant positive association (p<0.01 and 0.05) was identified between antioxidant activity and carbohydrate-metabolising enzyme inhibitory activity.
The obtained result suggests N.
latifolia leaf could serve as an alternative candidate for managing diabetes mellitus due to its antioxidant and anti-inflammatory association with diabetes-linked enzymes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iheagwam, Franklyn Nonso& Israel, Emmanuel Nsedu& Kayode, Kazeem Oyindamola& De Campos, Opeyemi Christianah& Ogunlana, Olubanke Olujoke& Chinedu, Shalom Nwodo. 2020. Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204899
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iheagwam, Franklyn Nonso…[et al.]. Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204899
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iheagwam, Franklyn Nonso& Israel, Emmanuel Nsedu& Kayode, Kazeem Oyindamola& De Campos, Opeyemi Christianah& Ogunlana, Olubanke Olujoke& Chinedu, Shalom Nwodo. Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204899
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204899
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر