Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes
Joint Authors
Iheagwam, Franklyn Nonso
Israel, Emmanuel Nsedu
De Campos, Opeyemi Christianah
Ogunlana, Olubanke Olujoke
Chinedu, Shalom Nwodo
Kayode, Kazeem Oyindamola
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
This study was carried out to assess the in vitro antioxidant, anti-inflammatory and antidiabetic effects of Nauclea latifolia (Sm.) leaf extracts.
Ethanolic (NLE) and aqueous (NLA) extract of N.
latifolia leaves were prepared and assessed for their anti-inflammatory activity, antioxidant potential, α-amylase and α-glucosidase inhibitory activities, and the mechanism of enzyme inhibition in vitro using standard established methods.
From the results, phytochemicals such as flavonoids, phenolics, glycosides, and tannins were detected in both extracts of N.
latifolia with NLE having a significantly (p<0.05) higher phytochemical content.
NLE displayed significantly (p<0.05) better total antioxidant capacity, reducing power, 2,2-diphenyl-2-picrylhydrazyl, and hydrogen peroxide radical scavenging activities.
For anti-inflammatory activities, 70.54±2.45% albumin denaturation inhibition was observed for NLE while 68.05±1.03% was recorded for NLA.
Likewise, 16.07±1.60 and 14.08±1.76% were obtained against hypotonic solution and heat-induced erythrocyte haemolysis, respectively, for NLE while 20.59±4.60 and 24.07±1.60% were respective NLA values.
NLE (IC50: 4.20±0.18 and 1.19±0.11 mg/mL) and NLA (IC50: 11.21±0.35 and 2.64±0.48 mg/mL) α-glucosidase and α-amylase inhibitory activities were dose-dependent with uncompetitive and competitive inhibition elicited, respectively, by the extracts.
A significant positive association (p<0.01 and 0.05) was identified between antioxidant activity and carbohydrate-metabolising enzyme inhibitory activity.
The obtained result suggests N.
latifolia leaf could serve as an alternative candidate for managing diabetes mellitus due to its antioxidant and anti-inflammatory association with diabetes-linked enzymes.
American Psychological Association (APA)
Iheagwam, Franklyn Nonso& Israel, Emmanuel Nsedu& Kayode, Kazeem Oyindamola& De Campos, Opeyemi Christianah& Ogunlana, Olubanke Olujoke& Chinedu, Shalom Nwodo. 2020. Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204899
Modern Language Association (MLA)
Iheagwam, Franklyn Nonso…[et al.]. Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204899
American Medical Association (AMA)
Iheagwam, Franklyn Nonso& Israel, Emmanuel Nsedu& Kayode, Kazeem Oyindamola& De Campos, Opeyemi Christianah& Ogunlana, Olubanke Olujoke& Chinedu, Shalom Nwodo. Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204899