Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion
المؤلفون المشاركون
Parsa, Yekta
Zarrindast, Mohammad Reza
Jangholi, Ehsan
Sharifi, Zahra Nadia
Hoseinian, Mohammad
Rahimi, Hamid Reza
Mowla, Ashkan
Aryan, Hoda
Javidi, Mohammad Amin
Ghaffarpasand, Fariborz
Arani, Hamid Zaferani
Shahi, Farshad
Movassaghi, Shabnam
Yadollah-Damavandi, Soheila
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The prefrontal cortex is the largest lobe of the brain and is consequently involved in stroke.
There is no comprehensive practical pharmacological strategy for ameliorating prefrontal cortex injury induced by cerebral ischemia.
Therefore, we studied the neuroprotective properties of verapamil (Ver) on mitochondrial dysfunction and morphological features of apoptosis in transient global ischemia/reperfusion (I/R).
Ninety-six Wistar rats were allocated into four groups: control, I/R, I/R+Ver (10 mg/kg twice 1 hour prior to ischemia and 1 hour after reperfusion phase), and I/R+NaCl (vehicle).
Animals were sacrificed, and mitochondrial dysfunction parameters (i.e., mitochondrial swelling, mitochondrial membrane potential, ATP concentration, ROS production, and cytochrome c release), antioxidant defense (i.e., superoxide dismutase, malondialdehyde, glutathione peroxidase, catalase, and caspase-3 activation), and morphological features of apoptosis were determined.
The results showed that mitochondrial damage, impairment of antioxidant defense system, and apoptosis were significantly more prevalent in the I/R group in comparison with the other groups.
Ver decreased mitochondrial damage by reducing oxidative stress, augmented the activity of antioxidant enzymes in the brain, and decreased apoptosis in the I/R neurons.
The current study confirmed the role of oxidative stress and mitochondrial dysfunction in I/R progression and indicated the possible antioxidative mechanism of the neuroprotective activities of Ver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jangholi, Ehsan& Sharifi, Zahra Nadia& Hoseinian, Mohammad& Zarrindast, Mohammad Reza& Rahimi, Hamid Reza& Mowla, Ashkan…[et al.]. 2020. Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204969
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jangholi, Ehsan…[et al.]. Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204969
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jangholi, Ehsan& Sharifi, Zahra Nadia& Hoseinian, Mohammad& Zarrindast, Mohammad Reza& Rahimi, Hamid Reza& Mowla, Ashkan…[et al.]. Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204969
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204969
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر