Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion
Joint Authors
Parsa, Yekta
Zarrindast, Mohammad Reza
Jangholi, Ehsan
Sharifi, Zahra Nadia
Hoseinian, Mohammad
Rahimi, Hamid Reza
Mowla, Ashkan
Aryan, Hoda
Javidi, Mohammad Amin
Ghaffarpasand, Fariborz
Arani, Hamid Zaferani
Shahi, Farshad
Movassaghi, Shabnam
Yadollah-Damavandi, Soheila
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The prefrontal cortex is the largest lobe of the brain and is consequently involved in stroke.
There is no comprehensive practical pharmacological strategy for ameliorating prefrontal cortex injury induced by cerebral ischemia.
Therefore, we studied the neuroprotective properties of verapamil (Ver) on mitochondrial dysfunction and morphological features of apoptosis in transient global ischemia/reperfusion (I/R).
Ninety-six Wistar rats were allocated into four groups: control, I/R, I/R+Ver (10 mg/kg twice 1 hour prior to ischemia and 1 hour after reperfusion phase), and I/R+NaCl (vehicle).
Animals were sacrificed, and mitochondrial dysfunction parameters (i.e., mitochondrial swelling, mitochondrial membrane potential, ATP concentration, ROS production, and cytochrome c release), antioxidant defense (i.e., superoxide dismutase, malondialdehyde, glutathione peroxidase, catalase, and caspase-3 activation), and morphological features of apoptosis were determined.
The results showed that mitochondrial damage, impairment of antioxidant defense system, and apoptosis were significantly more prevalent in the I/R group in comparison with the other groups.
Ver decreased mitochondrial damage by reducing oxidative stress, augmented the activity of antioxidant enzymes in the brain, and decreased apoptosis in the I/R neurons.
The current study confirmed the role of oxidative stress and mitochondrial dysfunction in I/R progression and indicated the possible antioxidative mechanism of the neuroprotective activities of Ver.
American Psychological Association (APA)
Jangholi, Ehsan& Sharifi, Zahra Nadia& Hoseinian, Mohammad& Zarrindast, Mohammad Reza& Rahimi, Hamid Reza& Mowla, Ashkan…[et al.]. 2020. Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204969
Modern Language Association (MLA)
Jangholi, Ehsan…[et al.]. Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1204969
American Medical Association (AMA)
Jangholi, Ehsan& Sharifi, Zahra Nadia& Hoseinian, Mohammad& Zarrindast, Mohammad Reza& Rahimi, Hamid Reza& Mowla, Ashkan…[et al.]. Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global IschemiaReperfusion. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1204969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1204969