A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16
المؤلفون المشاركون
Zhou, Xiao-Gang
Zhu, Qing
Chen, Jian-Ning
Wu, Gui-Sheng
Qu, Yuan
Luo, Huai-Rong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Naringin is a dihydroflavonoid, which is rich in several plant species used for herbal medicine.
It has a wide range of biological activities, including antineoplastic, anti-inflammatory, antiphotoaging, and antioxidative activities.
So it would be interesting to know if naringin has an effect on aging and aging-related diseases.
We examined the effect of naringin on the aging of Caenorhabditis elegans (C.
elegans).
Our results showed that naringin could extend the lifespan of C.
elegans.
Moreover, naringin could also increase the thermal and oxidative stress tolerance, reduce the accumulation of lipofuscin, and delay the progress of aging-related diseases in C.
elegans models of AD and PD.
Naringin could not significantly extend the lifespan of long-lived mutants from genes in insulin/IGF-1 signaling (IIS) and nutrient-sensing pathways, such as daf-2, akt-2, akt-1, eat-2, sir-2.1, and rsks-1.
Naringin treatment prolonged the lifespan of long-lived glp-1 mutants, which have decreased reproductive stem cells.
Naringin could not extend the lifespan of a null mutant of the fox-head transcription factor DAF-16.
Moreover, naringin could increase the mRNA expression of genes regulated by daf-16 and itself.
In conclusion, we show that a natural product naringin could extend the lifespan of C.
elegans and delay the progression of aging-related diseases in C.
elegans models via DAF-16.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Qing& Qu, Yuan& Zhou, Xiao-Gang& Chen, Jian-Ning& Luo, Huai-Rong& Wu, Gui-Sheng. 2020. A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205024
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Qing…[et al.]. A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205024
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Qing& Qu, Yuan& Zhou, Xiao-Gang& Chen, Jian-Ning& Luo, Huai-Rong& Wu, Gui-Sheng. A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205024
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205024
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر