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A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16
Joint Authors
Zhou, Xiao-Gang
Zhu, Qing
Chen, Jian-Ning
Wu, Gui-Sheng
Qu, Yuan
Luo, Huai-Rong
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Naringin is a dihydroflavonoid, which is rich in several plant species used for herbal medicine.
It has a wide range of biological activities, including antineoplastic, anti-inflammatory, antiphotoaging, and antioxidative activities.
So it would be interesting to know if naringin has an effect on aging and aging-related diseases.
We examined the effect of naringin on the aging of Caenorhabditis elegans (C.
elegans).
Our results showed that naringin could extend the lifespan of C.
elegans.
Moreover, naringin could also increase the thermal and oxidative stress tolerance, reduce the accumulation of lipofuscin, and delay the progress of aging-related diseases in C.
elegans models of AD and PD.
Naringin could not significantly extend the lifespan of long-lived mutants from genes in insulin/IGF-1 signaling (IIS) and nutrient-sensing pathways, such as daf-2, akt-2, akt-1, eat-2, sir-2.1, and rsks-1.
Naringin treatment prolonged the lifespan of long-lived glp-1 mutants, which have decreased reproductive stem cells.
Naringin could not extend the lifespan of a null mutant of the fox-head transcription factor DAF-16.
Moreover, naringin could increase the mRNA expression of genes regulated by daf-16 and itself.
In conclusion, we show that a natural product naringin could extend the lifespan of C.
elegans and delay the progression of aging-related diseases in C.
elegans models via DAF-16.
American Psychological Association (APA)
Zhu, Qing& Qu, Yuan& Zhou, Xiao-Gang& Chen, Jian-Ning& Luo, Huai-Rong& Wu, Gui-Sheng. 2020. A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205024
Modern Language Association (MLA)
Zhu, Qing…[et al.]. A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1205024
American Medical Association (AMA)
Zhu, Qing& Qu, Yuan& Zhou, Xiao-Gang& Chen, Jian-Ning& Luo, Huai-Rong& Wu, Gui-Sheng. A Dihydroflavonoid Naringin Extends the Lifespan of C. elegans and Delays the Progression of Aging-Related Diseases in PDAD Models via DAF-16. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1205024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205024