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Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion
المؤلفون المشاركون
Guo, Haoyan
Zhang, Wenlong
Xu, Jiaqian
Xing, Zhengcao
He, Jianli
Cheng, Jinke
Cai, Rong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Nuclear factor erythroid 2-related factor 2 (NRF2) is a crucial transcription factor for cell adaptation and defense against oxidative stress.
NRF2 activation confers Kras/Lkb1/Keap1 (KLK) mutant tumor cells with greater resistance to oxidative insults.
We previously reported that SUMOylation at lysine residue 110 is important for the ability of NRF2 to promote reactive oxygen species (ROS) clearance in hepatocellular carcinoma.
In this study, we investigated whether SUMOylation is necessary for the ability of NRF2 to inhibit KLK lung adenocarcinoma (LUAD) cell migration and invasion.
Our experiments showed that mild oxidative stress reduced NRF2 SUMOylation, which promoted KLK LUAD cell migration and invasion.
Mechanistically, NRF2 SUMOylation increased the antioxidant ability of NRF2 and reduced cellular ROS levels, mainly by transcriptionally activating Cat in KLK LUAD cells.
With reduced NRF2 SUMOylation, increased ROS acted as signaling molecules to activate the JNK/c-Jun axis, which enhanced cell mobility and cell adhesion, to promote LUAD cell migration and invasion.
Taken together, the results of this study reveal a novel signaling process in which reduced NRF2 SUMOylation permits increased KLK LUAD cell migration and invasion under mild oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Jiaqian& Guo, Haoyan& Xing, Zhengcao& Zhang, Wenlong& He, Jianli& Cheng, Jinke…[et al.]. 2020. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Jiaqian…[et al.]. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1205083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Jiaqian& Guo, Haoyan& Xing, Zhengcao& Zhang, Wenlong& He, Jianli& Cheng, Jinke…[et al.]. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote KrasLkb1Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1205083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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