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Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats
المؤلفون المشاركون
Jeremic, Jovana
Bolevich, Sergey
Ristic, Jelena
Folic, Marko
Radonjic, Katarina
Rosic, Milenko I.
Alisultanovich, Omarov Israpil
Draginic, Nevena
Andjic, Marijana
Milosavljevic, Isidora
Jakovljevic, Vladimir Lj.
Zivkovic, Vladimir I.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Taken into consideration that oxidative stress response after preconditioning with phosphodiesterase inhibitors (PDEIs) and moderate physical activity has still not been clarified, the aim of this study was to assess the effects of PDEIs alone or in combination with physical activity, on systemic redox status.
The study was carried out on 96 male Wistar albino rats classified into two groups.
The first group included animals exposed only to pharmacological preconditioning (PreC) maneuver (sedentary control (CTRL, 1 ml/day saline, n=12), nicardipine (6 mg/kg/day of NIC, n=12), vinpocetine (10 mg/kg/day of VIN, n=12), and nimodipine (NIM 10 mg/kg/day of, n=12).
The second included animals exposed to preconditioning with moderate-intensity training (MIT) on treadmill for 8 weeks.
After 5 weeks from the start of training, the animals were divided into four subgroups depending on the medication to be used for pharmacological PreC: moderate-intensity training (MIT+ 1 ml/day saline, n=12), nicardipine (MIT+ 6 mg/kg/day of NIC, n=12), vinpocetine (MIT+ 10 mg/kg/day of VIN, n=12), and nimodipine (MIT+ 10 mg/kg/day of NIM, n=12).
After three weeks of pharmacological preconditioning, the animals were sacrificed.
The following oxidative stress parameters were measured spectrophotometrically: nitrites (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), index of lipid peroxidation (TBARS), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH).
Our results showed that PDE1 and MIT preconditioning decreased the release of prooxidants and improved the activity of antioxidant enzymes thus preventing systemic oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ristic, Jelena& Folic, Marko& Radonjic, Katarina& Rosic, Milenko I.& Bolevich, Sergey& Alisultanovich, Omarov Israpil…[et al.]. 2020. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205101
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ristic, Jelena…[et al.]. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205101
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ristic, Jelena& Folic, Marko& Radonjic, Katarina& Rosic, Milenko I.& Bolevich, Sergey& Alisultanovich, Omarov Israpil…[et al.]. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205101
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205101
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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