Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats
Joint Authors
Jeremic, Jovana
Bolevich, Sergey
Ristic, Jelena
Folic, Marko
Radonjic, Katarina
Rosic, Milenko I.
Alisultanovich, Omarov Israpil
Draginic, Nevena
Andjic, Marijana
Milosavljevic, Isidora
Jakovljevic, Vladimir Lj.
Zivkovic, Vladimir I.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Taken into consideration that oxidative stress response after preconditioning with phosphodiesterase inhibitors (PDEIs) and moderate physical activity has still not been clarified, the aim of this study was to assess the effects of PDEIs alone or in combination with physical activity, on systemic redox status.
The study was carried out on 96 male Wistar albino rats classified into two groups.
The first group included animals exposed only to pharmacological preconditioning (PreC) maneuver (sedentary control (CTRL, 1 ml/day saline, n=12), nicardipine (6 mg/kg/day of NIC, n=12), vinpocetine (10 mg/kg/day of VIN, n=12), and nimodipine (NIM 10 mg/kg/day of, n=12).
The second included animals exposed to preconditioning with moderate-intensity training (MIT) on treadmill for 8 weeks.
After 5 weeks from the start of training, the animals were divided into four subgroups depending on the medication to be used for pharmacological PreC: moderate-intensity training (MIT+ 1 ml/day saline, n=12), nicardipine (MIT+ 6 mg/kg/day of NIC, n=12), vinpocetine (MIT+ 10 mg/kg/day of VIN, n=12), and nimodipine (MIT+ 10 mg/kg/day of NIM, n=12).
After three weeks of pharmacological preconditioning, the animals were sacrificed.
The following oxidative stress parameters were measured spectrophotometrically: nitrites (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), index of lipid peroxidation (TBARS), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH).
Our results showed that PDE1 and MIT preconditioning decreased the release of prooxidants and improved the activity of antioxidant enzymes thus preventing systemic oxidative stress.
American Psychological Association (APA)
Ristic, Jelena& Folic, Marko& Radonjic, Katarina& Rosic, Milenko I.& Bolevich, Sergey& Alisultanovich, Omarov Israpil…[et al.]. 2020. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205101
Modern Language Association (MLA)
Ristic, Jelena…[et al.]. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205101
American Medical Association (AMA)
Ristic, Jelena& Folic, Marko& Radonjic, Katarina& Rosic, Milenko I.& Bolevich, Sergey& Alisultanovich, Omarov Israpil…[et al.]. Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205101