New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry
المؤلفون المشاركون
Blangy-Letheule, Angélique
Persello, Antoine
Rozec, Bertrand
Waard, Michel De
Lauzier, Benjamin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Septic shock is a systemic inflammatory response syndrome associated with circulatory failure leading to organ failure with a 40% mortality rate.
Early diagnosis and prognosis of septic shock are necessary for specific and timely treatment.
However, no predictive biomarker is available.
In recent years, improvements in proteomics-based mass spectrometry have improved the detection of such biomarkers.
This approach can be performed on different samples such as tissue or biological fluids.
Working directly from human samples is complicated owing to interindividual variability.
Indeed, patients are admitted at different stages of disease development and with signs of varying severity from one patient to another.
All of these elements interfere with the identification of early, sensitive, and specific septic shock biomarkers.
For these reasons, animal models of sepsis, although imperfect, are used to control the kinetics of the development of the pathology and to standardise experimentation, facilitating the identification of potential biomarkers.
These elements underline the importance of the choice of animal model used and the sample to be studied during preclinical studies.
The aim of this review is to discuss the relevance of different approaches to enable the identification of biomarkers that could indirectly be relevant to the clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Blangy-Letheule, Angélique& Persello, Antoine& Rozec, Bertrand& Waard, Michel De& Lauzier, Benjamin. 2020. New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Blangy-Letheule, Angélique…[et al.]. New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Blangy-Letheule, Angélique& Persello, Antoine& Rozec, Bertrand& Waard, Michel De& Lauzier, Benjamin. New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر