New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry
Joint Authors
Blangy-Letheule, Angélique
Persello, Antoine
Rozec, Bertrand
Waard, Michel De
Lauzier, Benjamin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Septic shock is a systemic inflammatory response syndrome associated with circulatory failure leading to organ failure with a 40% mortality rate.
Early diagnosis and prognosis of septic shock are necessary for specific and timely treatment.
However, no predictive biomarker is available.
In recent years, improvements in proteomics-based mass spectrometry have improved the detection of such biomarkers.
This approach can be performed on different samples such as tissue or biological fluids.
Working directly from human samples is complicated owing to interindividual variability.
Indeed, patients are admitted at different stages of disease development and with signs of varying severity from one patient to another.
All of these elements interfere with the identification of early, sensitive, and specific septic shock biomarkers.
For these reasons, animal models of sepsis, although imperfect, are used to control the kinetics of the development of the pathology and to standardise experimentation, facilitating the identification of potential biomarkers.
These elements underline the importance of the choice of animal model used and the sample to be studied during preclinical studies.
The aim of this review is to discuss the relevance of different approaches to enable the identification of biomarkers that could indirectly be relevant to the clinical setting.
American Psychological Association (APA)
Blangy-Letheule, Angélique& Persello, Antoine& Rozec, Bertrand& Waard, Michel De& Lauzier, Benjamin. 2020. New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205190
Modern Language Association (MLA)
Blangy-Letheule, Angélique…[et al.]. New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1205190
American Medical Association (AMA)
Blangy-Letheule, Angélique& Persello, Antoine& Rozec, Bertrand& Waard, Michel De& Lauzier, Benjamin. New Approaches to Identify Sepsis Biomarkers: The Importance of Model and Sample Source for Mass Spectrometry. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1205190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205190