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Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin
المؤلفون المشاركون
Díaz-Quintana, Antonio
Pérez-Mejías, Gonzalo
Guerra-Castellano, Alejandra
De la Rosa, Miguel A.
Díaz-Moreno, Irene
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-22
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically encoded cell death programs.
In this context, the interplay between cardiolipin and another mitochondrial factor—cytochrome c—is a key process in the early stages of apoptosis, and it is a matter of intense research.
Cytochrome c interacts with lipid membranes by electrostatic interactions, hydrogen bonds, and hydrophobic effects.
Experimental conditions (including pH, lipid composition, and post-translational modifications) determine which specific amino acid residues are involved in the interaction and influence the heme iron coordination state.
In fact, up to four binding sites (A, C, N, and L), driven by different interactions, have been reported.
Nevertheless, key aspects of the mechanism for cardiolipin oxidation by the hemeprotein are well established.
First, cytochrome c acts as a pseudoperoxidase, a process orchestrated by tyrosine residues which are crucial for peroxygenase activity and sensitivity towards oxidation caused by protein self-degradation.
Second, flexibility of two weakest folding units of the hemeprotein correlates with its peroxidase activity and the stability of the iron coordination sphere.
Third, the diversity of the mode of interaction parallels a broad diversity in the specific reaction pathway.
Thus, current knowledge has already enabled the design of novel drugs designed to successfully inhibit cardiolipin oxidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Díaz-Quintana, Antonio& Pérez-Mejías, Gonzalo& Guerra-Castellano, Alejandra& De la Rosa, Miguel A.& Díaz-Moreno, Irene. 2020. Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1205213
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Díaz-Quintana, Antonio…[et al.]. Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1205213
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Díaz-Quintana, Antonio& Pérez-Mejías, Gonzalo& Guerra-Castellano, Alejandra& De la Rosa, Miguel A.& Díaz-Moreno, Irene. Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1205213
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205213
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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