Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin
Joint Authors
Díaz-Quintana, Antonio
Pérez-Mejías, Gonzalo
Guerra-Castellano, Alejandra
De la Rosa, Miguel A.
Díaz-Moreno, Irene
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-22
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically encoded cell death programs.
In this context, the interplay between cardiolipin and another mitochondrial factor—cytochrome c—is a key process in the early stages of apoptosis, and it is a matter of intense research.
Cytochrome c interacts with lipid membranes by electrostatic interactions, hydrogen bonds, and hydrophobic effects.
Experimental conditions (including pH, lipid composition, and post-translational modifications) determine which specific amino acid residues are involved in the interaction and influence the heme iron coordination state.
In fact, up to four binding sites (A, C, N, and L), driven by different interactions, have been reported.
Nevertheless, key aspects of the mechanism for cardiolipin oxidation by the hemeprotein are well established.
First, cytochrome c acts as a pseudoperoxidase, a process orchestrated by tyrosine residues which are crucial for peroxygenase activity and sensitivity towards oxidation caused by protein self-degradation.
Second, flexibility of two weakest folding units of the hemeprotein correlates with its peroxidase activity and the stability of the iron coordination sphere.
Third, the diversity of the mode of interaction parallels a broad diversity in the specific reaction pathway.
Thus, current knowledge has already enabled the design of novel drugs designed to successfully inhibit cardiolipin oxidation.
American Psychological Association (APA)
Díaz-Quintana, Antonio& Pérez-Mejías, Gonzalo& Guerra-Castellano, Alejandra& De la Rosa, Miguel A.& Díaz-Moreno, Irene. 2020. Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1205213
Modern Language Association (MLA)
Díaz-Quintana, Antonio…[et al.]. Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1205213
American Medical Association (AMA)
Díaz-Quintana, Antonio& Pérez-Mejías, Gonzalo& Guerra-Castellano, Alejandra& De la Rosa, Miguel A.& Díaz-Moreno, Irene. Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1205213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205213