Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury
المؤلفون المشاركون
Lv, Yi
Wu, Rongqian
Chen, Xue
Bi, Jianbin
Zhang, Jia
Ren, Yifan
Yang, Lifei
Wang, Tao
Li, Teng
Wang, Mengzhou
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-02
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
An aged liver has decreased reparative capacity during ischemia-reperfusion (IR) injury.
A recent study showed that plasma irisin levels predict telomere length in healthy adults.
The aim of the present study is to clarify the role of irisin, telomerase activity, and autophagy during hepatic IR in the elderly.
To study this, hepatic IR was established in 22-month- and 3-month-old rats and primary hepatocytes were isolated.
The results showed that the old rats exhibited more serious liver injury and lower levels of irisin expression, telomerase activity, autophagy ability, and mitochondrial function than young rats during hepatic IR.
Irisin activated autophagy and improved mitochondrial function via increasing telomerase activity in aged hepatocytes.
Inhibition of telomerase activity by BIBP1532 abolished the protective role of irisin in hepatocytes during hypoxia and reoxygenation.
Additionally, this study proved irisin increased the telomerase activity via inhibition of the phosphorylation of JNK during hepatic IR.
Administration of exogenous irisin significantly mitigated the inflammation, oxidative stress, apoptosis, and liver injury in an old rat model of hepatic IR.
In conclusion, irisin improves autophagy of aged hepatocytes via increasing telomerase activity in hepatic IR.
Irisin exhibits conspicuous benefits in increasing reparative capacity of an aged liver during hepatic IR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bi, Jianbin& Yang, Lifei& Wang, Tao& Zhang, Jia& Li, Teng& Ren, Yifan…[et al.]. 2020. Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bi, Jianbin…[et al.]. Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bi, Jianbin& Yang, Lifei& Wang, Tao& Zhang, Jia& Li, Teng& Ren, Yifan…[et al.]. Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر