Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury
Joint Authors
Lv, Yi
Wu, Rongqian
Chen, Xue
Bi, Jianbin
Zhang, Jia
Ren, Yifan
Yang, Lifei
Wang, Tao
Li, Teng
Wang, Mengzhou
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-01-02
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
An aged liver has decreased reparative capacity during ischemia-reperfusion (IR) injury.
A recent study showed that plasma irisin levels predict telomere length in healthy adults.
The aim of the present study is to clarify the role of irisin, telomerase activity, and autophagy during hepatic IR in the elderly.
To study this, hepatic IR was established in 22-month- and 3-month-old rats and primary hepatocytes were isolated.
The results showed that the old rats exhibited more serious liver injury and lower levels of irisin expression, telomerase activity, autophagy ability, and mitochondrial function than young rats during hepatic IR.
Irisin activated autophagy and improved mitochondrial function via increasing telomerase activity in aged hepatocytes.
Inhibition of telomerase activity by BIBP1532 abolished the protective role of irisin in hepatocytes during hypoxia and reoxygenation.
Additionally, this study proved irisin increased the telomerase activity via inhibition of the phosphorylation of JNK during hepatic IR.
Administration of exogenous irisin significantly mitigated the inflammation, oxidative stress, apoptosis, and liver injury in an old rat model of hepatic IR.
In conclusion, irisin improves autophagy of aged hepatocytes via increasing telomerase activity in hepatic IR.
Irisin exhibits conspicuous benefits in increasing reparative capacity of an aged liver during hepatic IR.
American Psychological Association (APA)
Bi, Jianbin& Yang, Lifei& Wang, Tao& Zhang, Jia& Li, Teng& Ren, Yifan…[et al.]. 2020. Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205239
Modern Language Association (MLA)
Bi, Jianbin…[et al.]. Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1205239
American Medical Association (AMA)
Bi, Jianbin& Yang, Lifei& Wang, Tao& Zhang, Jia& Li, Teng& Ren, Yifan…[et al.]. Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1205239
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205239