Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms
المؤلفون المشاركون
Song, Yan-Jun
Zhong, Chong-Bin
Wu, Wei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-13
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Diabetic cardiomyopathy (DCM) is a common cardiovascular complication of diabetic mellitus that is characterized by diastolic disorder in the early stage and clinical heart failure in the later stage.
Presently, DCM is considered one of the major causes of death in diabetic patients.
Resveratrol (RSV), a naturally occurring stilbene, is widely reported as a cardioprotective substance in many heart diseases.
Thus far, the specific roles of RSV in DCM prevention and treatment have attracted great attention.
Here, we discuss the roles of RSV in DCM by focusing its downstream targets from both in vivo and in vitro studies.
Among such targets, Sirtuins 1/3 and AMP-activated kinase have been identified as key mediators that induce cardioprotection during hyperglycemia.
In addition, many other signaling molecules (e.g., forkhead box-O3a and extracellular regulated protein kinases) are also regulated in the presence of RSV and exert beneficial effects such as opposing oxidative stress, inflammation, and apoptosis in cardiomyocytes exposed to high-glucose conditions.
The beneficial potential of an RSV/stem cell cotherapy is also reviewed as a promising therapeutic strategy for preventing the development of DCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Yan-Jun& Zhong, Chong-Bin& Wu, Wei. 2020. Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205272
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Yan-Jun…[et al.]. Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1205272
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Yan-Jun& Zhong, Chong-Bin& Wu, Wei. Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205272
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205272
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر