Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms
Joint Authors
Song, Yan-Jun
Zhong, Chong-Bin
Wu, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-13
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Diabetic cardiomyopathy (DCM) is a common cardiovascular complication of diabetic mellitus that is characterized by diastolic disorder in the early stage and clinical heart failure in the later stage.
Presently, DCM is considered one of the major causes of death in diabetic patients.
Resveratrol (RSV), a naturally occurring stilbene, is widely reported as a cardioprotective substance in many heart diseases.
Thus far, the specific roles of RSV in DCM prevention and treatment have attracted great attention.
Here, we discuss the roles of RSV in DCM by focusing its downstream targets from both in vivo and in vitro studies.
Among such targets, Sirtuins 1/3 and AMP-activated kinase have been identified as key mediators that induce cardioprotection during hyperglycemia.
In addition, many other signaling molecules (e.g., forkhead box-O3a and extracellular regulated protein kinases) are also regulated in the presence of RSV and exert beneficial effects such as opposing oxidative stress, inflammation, and apoptosis in cardiomyocytes exposed to high-glucose conditions.
The beneficial potential of an RSV/stem cell cotherapy is also reviewed as a promising therapeutic strategy for preventing the development of DCM.
American Psychological Association (APA)
Song, Yan-Jun& Zhong, Chong-Bin& Wu, Wei. 2020. Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205272
Modern Language Association (MLA)
Song, Yan-Jun…[et al.]. Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1205272
American Medical Association (AMA)
Song, Yan-Jun& Zhong, Chong-Bin& Wu, Wei. Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1205272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1205272